| 3/8/25 | Saturday | 1:00 PM | Away | PRP (Scrimmage) | PRP |
| 3/12/25 | Wednesday | 6:00 PM | Home | Franklin County (Scrimmage) | Frederick Douglass High School |
| 3/18/25 | Tuesday | 6:00 PM | Home | Madison Central | Frederick Douglass High School |
| 3/19/25 | Wednesday | 6:00 PM | Home | Tates Creek | Frederick Douglass High School |
| 3/21/25 | Friday | 5:30 PM | Away | LCA | LCA |
| 3/22/25 | Saturday | 1:00 PM | Home | Ballard | Frederick Douglass High School |
| 3/24/25 | Monday | 5:30PM | Home | Lexington Catholic | Frederick Douglass High School |
| 3/26/25 | Wednesday | 6:00PM | Home | St. Xavier | Frederick Douglass High School |
| 3/28/25 | Friday | 5:30 PM | Away | Paul Laurence Dunbar | Paul Laurence Dunbar High School |
| 3/29/25 | Saturday | 12 noon | Home | Lafayette | Frederick Douglass High School (Uncle Jerry Classic) |
| 3/29/25 | Saturday | 5:00 PM | Home | Conner | Frederick Douglass High School (Uncle Jerry Classic) |
| 4/1/25 | Tuesday | 5:30 PM | Home | Bryan Station | Frederick Douglass High School |
| 4/2/25 | Wednesday | 5:30 PM | Away | Bryan Station | Bryan Station High School |
| 4/4/25 | Friday | 6:00PM | Legends Field | Franklin County | Lexington Legends Field |
| 4/8/25 | Tuesday | 3:00 PM | Away (PCB) | Greenwood (KY) | Panama City Beach, Florida |
| 4/9/25 | Wednesday | 9:00 AM | Away (PCB) | Johns Creek (GA) | Panama City Beach, Florida |
| 4/9/25 | Wednesday | 6:00 PM | Away (PCB) | Cumberland Co. (KY) | Panama City Beach, Florida |
| 4/10/25 | Thursday | TBA | Away (PCB) | Bracket Game: TBA | Panama City Beach, Florida |
| 4/15/25 | Tuesday | 6:30 PM | Home | Trinity | Frederick Douglass High School |
| 4/16/25 | Wednesday | 6:30 PM | Away | Trinity | Trinity High School |
| 4/18/25 | Friday | 6:00 PM | Home | West Jessamine | Frederick Douglass High School |
| 4/19/25 | Saturday | 4:00 PM | Away | TBA | Lexington Christian Academy |
| 4/19/25 | Saturday | 7:00 PM | Away | LCA | Lexington Christian Academy |
| 4/22/25 | Tuesday | 5:30 PM | Home | Scott County | Frederick Douglass High School |
| 4/23/25 | Wednesday | 5:30 PM | Away | Scott County | Scott County High School |
| 4/24/25 | Thursday | 7:00 PM | Away | Christian Academy of Louisville | Christian Academy of Louisville |
| 4/26/25 | Saturday | 2:00 PM | Away | John Battle (VA) | Prestonsburg High School |
| 4/26/25 | Saturday | 4:00 PM | Away | Prestonburg | Prestonburg High School |
| 4/29/25 | Tuesday | 7:30 PM | Home | Henry Clay | Frederick Douglass High School |
| 4/29/25 | Wednesday | 7:30 PM | Away | Henry Clay | Henry Clay High School |
| 5/2/25 | Friday | 6:00 PM | Away | Franklin County | Franklin County High School |
| 5/3/25 | Saturday | 10:00 AM | Away | Mercer County | Mercer County High School |
| 5/3/25 | Saturday | 3:00 PM | Away | Martha Layne Collins | Mercer County High School |
| 5/6/25 | Tuesday | 5:30 PM | Away | Sayre | Sayre High School |
| 5/7/25 | Wednesday | 5:30 PM | Home | Sayre | Frederick Douglass High School |
| 5/9/25 | Friday (Senior Night) | 5:30 PM | Home (FCIT) | Woodford County | Frederick Douglass High School |
| 5/10/25 | Saturday | 11:00 AM | Home (FCIT) | Pikeville | Frederick Douglass High School |
| 5/10/25 | Saturday | 6:30 PM | Home (FCIT) | Ryle | Frederick Douglass High School |
| 5/12/25 | Monday | 7:00 PM | Away | Russell County | Russell County High School |
| 5/14/25 | Wednesday | 7:00 PM | Home | Whitley County | Frederick Douglass High School |
| 5/16/25 | Friday | TBA | Home | Frankfort | Frederick Douglass High School |
| 5/18/25 to 5/21/25 | Sunday to Wednesday | TBA | Home | 43rd District Tournament | Frederick Douglass High School |
